Study on the homeostasis mechanism of in vivo degradation of PCL microsphere fillers

Shuang Wu, Qi Guo, Rongling Liu, Zhisheng Yan, Ranran Tang, Shuo Pang, Wenjie Chen, Tun Yuan, National Engineering Research Center for Biomaterials, Sichuan University, College of Biomedical Engineering, Sichuan University, Sichuan Testing Centre for Biomaterials and Medical Devices, Chengdu Zhongxing Meiyuan Biotechnology Co, Xihong Biopharma

Journal of Biomaterials Applications

Published online on July 09, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
Polycaprolactone (PCL) has been widely applied in the fields of medical aesthetics and clinical filling due to its excellent biocompatibility, controllable degradability, and favorable mechanical properties. However, the high crystallinity and ...