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{"p"=>"The purpose of this review was to provide a systematic and quantitative summary of recent literature relating to cognitive outcomes following paediatric mild traumatic brain injury (mTBI). Variable findings and diverse methodologies have thus far made it difficult to meaningfully integrate the extant literature. In this context, there is a need to examine the factors that define heterogeneity in this population and to critically evaluate the methodologies from which variable outcomes are derived. Studies identified in this review (PROSPERO, identification number CRD42015030098) were obtained through systematic searches of PubMed, PsycInfo and Scopus. Inclusion criteria specified that studies were to report on cognitive functioning using validated neuropsychological measures, with children aged 8–18 years of age and in a case–control design protocol. In this review, 62 observational studies published pre-2025 were summarised in terms of participant, injury-related and methodological characteristics, with 49 of these studies also contributing to meta-analyses on nine cognitive-factor domains at five distinct time points post-injury. Data from 14,234 participants were represented across all studies, including 5,000 injury cases, and 9,234 controls. Findings from this review revealed that studies reporting on cognitive outcomes varied largely as a function of methodology. There appears to have been little refinement in methodologies over the last decade, with multiple possible sources of heterogeneity identified. Therefore, in line with previous research, the findings of this review suggest little to no evidence of clinically meaningful long-term cognitive impacts post mTBI. The review highlights a number of areas for improvement in future research."}

American Journal of Physiology-Cell Physiology, Ahead of Print.

American Journal of Physiology-Cell Physiology, Ahead of Print.

American Journal of Physiology-Cell Physiology, Ahead of Print.

{"p"=>"In recent years, scholars have called out the nefarious ways in which crimmigration practices—the day-to-day tactics that vet immigrants into the criminal justice system— have taken a toll on Latine communities in the interior parts of the United States. However, while most of this work has uncovered the impact on predominantly Mexican communities, very little is known about what happens to Salvadorans when gang enforcement becomes the dragnet to detain, deport, and deter Central American immigrants from local areas where their presence is strong. One such area is Long Island, New York, where Salvadorans’ experiences with anti-gang efforts show how they have become the collateral damage. In this article, I use qualitative data collected throughout Trump’s first term as president to argue that gang enforcement is weaponized against Salvadorans to expand the ‘crimmigration’ system. This leads to more ‘legal violence’—what Menjivar and Abrego (2012) conceptualized as a process of cumulative state-sanctioned precarities—and sustains a White Supremacist racial project (Provine & Doty, 2011)."}

{"p"=>"South Africa’s correctional system has long struggled with high rates of repeat offending. Yet the Department of Correctional Services (DCS) has operated without coherent, evidence-informed guidelines for defining or managing recidivism. This matter, without agreed definitions and measurement, is inconsistent; without clear policy guidance, program delivery is uneven; without shared data systems, the justice cluster cannot track what works. The present study addresses this gap through a two-phase qualitative design. Phase 1 drew on a scoping review of international recidivism management literature alongside semi-structured interviews with 29 purposively selected DCS personnel and external justice-sector stakeholders. Thematic analysis identified five critical areas of weakness: definitions, policy mandates, sentence planning processes, rehabilitation programming, and intergovernmental data-sharing. Building on these findings, Phase 2 used two consensus workshops: one with academic experts and a second with 30 multi-sector stakeholders at Goodwood Correctional Centre to refine and validate a set of draft guidelines. The process produced ten interlocking recommendations spanning definitional standards, a dedicated policy task team, RNR-based sentence management, mixed-modality rehabilitation, reformed visitation arrangements, employability pathways, wraparound community support, family mediation protocols, integrated information systems, and biometric identification. Across both workshop phases, one tension surfaced repeatedly: the pull between procedural precision and relational, human-centered support, and the need to assign ownership clearly enough that neither gets sacrificed for the other. The ten guidelines are structured into three implementation tiers: Tier 1 addressing definitions, policy, and training; Tier 2 covers programs, visitation, employment, and support networks; Tier 3 of the DCS implementation framework emphasises technology and digital systems to enhance recidivism management and to incorporate electronic tools for offender risk assessment, monitoring, and data administration, thereby enhancing the precision and efficacy of recidivism tracking. The objective is to establish a framework that DCS can effectively implement."}

{"p"=>"We investigated the involvement of adiponectin in the development of attention-deficit/hyperactivity disorder (ADHD), using a multi-pronged approach integrating cord blood adiponectin concentrations, polygenic risk scores derived from publicly available GWAS summary statistics, and Mendelian randomization. This study aimed to evaluate both upstream genetic influences and downstream adiponectin-level associations. Using a combination of longitudinal cord blood data (N = 531) and genome-wide association studies of ADHD (N = 55,374) and adiponectin (N = 46,434), we examined observational, genetic, and associations linking adiponectin with ADHD. Lower cord blood adiponectin levels were associated with higher ADHD symptoms at ages 5–6 and 8–9, and predicted membership in the increasing-symptom trajectory group. Gene-set analysis demonstrated pathway-level overlap between ADHD and adiponectin regulation. Genetic correlation analysis showed a significant negative correlation between ADHD and adiponectin levels. Mendelian randomization provided stronger evidence for an association of ADHD on adiponectin levels. Polygenic risk score analysis also demonstrated a negative association between genetic liability for ADHD and cord blood adiponectin levels. Additionally, lower adiponectin levels were found to be associated with elevated inflammatory markers in the cord blood samples obtained from the cohort study, which may provide a potential explanation for the higher prevalence of metabolic comorbidities observed in individuals with ADHD. These findings suggest that adiponectin may be associated with the biologyof ADHD and targeting adiponectin regulation may offer a novel approach for managing ADHD and its related health risks."}

There is no abstract available for this paper.

{"p"=>"Following the recent rise of incidents involving explosives in the Netherlands and Sweden, this comparative study provides a qualitative, mainly descriptive analysis of the phenomenon of explosive attacks in both countries. Based on twenty-five interviews with police professionals, the analysis identifies important similarities and differences between the two countries. Perpetrators, motives, targets, and organizational methods are largely comparable. In particular, the findings highlight the high willingness of youngsters and the correspondingly large pool of potential executors for such attacks. The prime motive is generally to convey a message, whereas the predominant targets were dwellings. The findings further underscore the key role of social media and digital platforms in the recruitment, planning, communication, and coordination of attacks. Notable differences concern the underlying conflicts: in the Netherlands, attacks are driven by both criminal and social conflicts; in Sweden, they are primarily linked to organized crime and local gangs. Furthermore, in the Netherlands, it is predominantly professional fireworks that are used as explosives, while a wider variety of explosive materials is employed in Sweden. This comparative study contributes to the emerging literature by providing valuable insights into explosive incidents and identifying avenues for future research."}

{"p"=>"UK law allows the confiscation of wages as proceeds of crime, notably for ‘illegal working’ by undocumented migrants. This article explores the context for criminalising work and confiscating wages, and the arguments against confiscation. It suggests that the confiscation of wages is conceptually, morally, and pragmatically questionable. The justifications for wage confiscation reflect an understanding of work as a finite resource controlled by the state rather than an act or relationship. The arguments against the confiscation of wages reflect the relational and social aspects of work, including the economic necessity to work and work’s potential for coercion and exploitation on the one hand, and dignity and self-realisation on the other. The article further suggests that only when the performance of the job itself is harmful to others may wages be confiscated."}

{"p"=>"The diffusion of deepfake technology has reshaped the structure of online risks and posed new institutional demands on existing network security management obligations. From a risk-oriented perspective, this article constructs a quantitative model for assessing artificial intelligence misuse risks and employs simulation-based experiments to systematically analyse governance outcomes under different levels of management obligations. The findings indicate that response timeliness, institutionalized procedures, and evidence preservation play a decisive role in damage mitigation, while reliance on technical detection alone is insufficient to achieve effective governance. The simulation model assesses the four types of governance systems for deepfake misuse across different scenarios through 10,000 iterations of the simulation experiment. Based on the experimental results, the article proposes a risk-tiered configuration of network security management obligations, providing empirical support for judicial determinations of the duty of reasonable care and for policy-level collaborative governance."}

{"p"=>"This study delves into the dynamics of collaboration within networks of professional money launderers known to the police in the Netherlands. Building on prior research, which revealed that financial facilitators aiding drug trafficking organizations can be linked in extensive collaborative networks, this study explores the factors influencing the formation of these ties. Using Dutch police registration data on 117 financial facilitators and applying Exponential Random Graph Models (ERGMs), the research identifies key personal and relational attributes and features of the overall collaboration network that explain tie formation. The findings reveal that financial facilitators who operate more business-like have a higher probability to form connections with other financial facilitators. Additionally, underground bankers seem to be more inclined to collaborate with other underground bankers in the Netherlands than with other types of financial facilitators. The study further suggests a trend toward the formation of triadic relationships over dyadic ones within these observed money laundering networks."}

{"p"=>"This article examines how wartime mobility shapes trust in the police during Russia's full-scale invasion of Ukraine. Existing scholarship has usually examined internally displaced persons, returnees, and non-displaced residents separately. We bring these trajectories into a single analytical frame and develop the concept of displacement-shaped legitimacy: the idea that police legitimacy is reconfigured through mobility, dependence on state institutions, visibility to public authority, and uneven exposure to insecurity. Drawing on open-ended responses from three waves of the Security and Trust Survey conducted in Kharkiv in 2022, 2023, and 2024, the article compares internally displaced persons (IDPs), returnees, and emplaced residents. The findings show that IDPs often report higher police trust, but this should not be read as straightforward institutional legitimacy. It reflects a more ambivalent form of functional trust produced by vulnerability, constrained choice, and reliance on visible state actors. By contrast, non-displaced residents' lower trust reflects cumulative exposure to insecurity and frustration with routine order maintenance under wartime strain. Returnees occupy an intermediate position, articulating increasingly concrete expectations of recovery, accountability, and normalised policing. The article contributes to police legitimacy theory by showing that legitimacy thresholds are not only procedurally produced but also spatially and temporally recalibrated through mobility. It also identifies practical and policy implications for civilian policing under prolonged emergency conditions."}

American Journal of Physiology-Lung Cellular and Molecular Physiology, Volume 331, Issue 2, Page L165-L177, August 2026.

{"p"=>"We examined the feasibility, acceptability and preliminary efficacy of Cognitive Behaviour Therapy for Perfectionism (CBT-P) for children delivered as an online 6-session guided parent-delivered intervention (GP-CBT-P). We conducted a two-arm randomised controlled trial comparing GP-CBT-P to waitlist for parents whose child was aged 7–12 and had elevated perfectionism. Primary outcomes were feasibility and acceptability; secondary outcomes were self-reported parental and child perfectionism, school satisfaction, happiness, stress, depressive symptoms, self-efficacy, and weight/shape concern. Assessment occurred at baseline (T1), 9- (T2, end of the intervention) and 18-weeks (T3) post-randomization. There were 89 enquiries over 14 months; 49 (54%) converted to randomisation (25 in GP-CBT-P, 24 in waitlist), and 60% of parents in the intervention group completed all 6 sessions. There were no differences between groups at baseline. Intent-to-treat analysis showed parents in GP-CBT-P had significantly lower levels of perfectionism at T2 and T3 than control (respective between groups effect sizes [ES] and 95% confidence intervals [CI] of 0.95 [0.37 to 1.53] and 0.65 [0.08 to 1.21]). Compared to control, children receiving GP-CBT-P reported significantly higher school satisfaction and academic self-efficacy, and lower stress, depression and weight/shape concerns; T3 ES ranged from 0.58 to 0.82. There were no significant differences between groups on child perfectionism. GP-CBT-P could benefit from strategies to enhance feasibility and acceptability given it promoted helpful change across parent and child self-reported outcomes. Reducing parental perfectionism may be a key driver of beneficial change in children. Further investigation with larger samples and longer-term follow-up is recommended."}

{"p"=>"Acid-sensing ion channels (ASICs) are proton-gated members of the degenerin/epithelial sodium channel family that are emerging as multifaceted regulators of cardiovascular function. ASICs expressed in baroreceptor, cardiac, and skeletal muscle afferents contribute to reflex control of blood pressure, cardiac function, and sympathetic outflow. In vascular smooth muscle and endothelial cells, ASICs integrate mechanical, metabolic, and humoral signals to regulate vascular tone. In the systemic circulation, ASIC2 contributes to pressure-dependent vasoconstriction of renal and cerebral arteries, supporting blood flow autoregulation and protection against organ injury. In contrast, ASIC1a promotes vasodilation, contributing to nitric oxide-dependent dilation in the cerebral arteries and to endothelium-dependent hyperpolarization and vasodilation in mesenteric arteries. In the pulmonary vascular smooth muscle cells, ASIC1a plays a central role in acute hypoxic- and receptor-mediated vasoconstriction, a role that becomes increasingly important in chronic hypoxia-induced pulmonary hypertension. Under these conditions, metabolic reprogramming drives extracellular acidification and enhances ASIC1a trafficking to the plasma membrane, promoting sustained depolarization, augmented store-operated calcium entry, and a hyperproliferative, apoptosis-resistant smooth muscle phenotype. ASIC1a additionally regulates mitochondrial homeostasis by modulating mitochondrial membrane potential, redox balance, and apoptotic susceptibility. Chronic hypoxia redistributes ASIC1a from mitochondria to the plasma membrane, leading to mitochondrial dysfunction and cell survival signaling, key features of pulmonary vascular disease. This review summarizes current understanding of ASIC function in the systemic and pulmonary vasculature and highlights non-proton-mediated signaling mechanisms, emerging mitochondria-specific mechanisms, sex-related differences, and therapeutic opportunities and challenges in targeting ASIC-dependent signaling pathways in vascular disease."}

American Journal of Physiology-Gastrointestinal and Liver Physiology, Ahead of Print.

American Journal of Physiology-Gastrointestinal and Liver Physiology, Volume 331, Issue 2, Page G165-G182, August 2026.

American Journal of Physiology-Cell Physiology, Volume 331, Issue 2, Page C328-C347, August 2026.

American Journal of Physiology-Renal Physiology, Volume 331, Issue 2, Page F175-F189, August 2026.

American Journal of Physiology-Gastrointestinal and Liver Physiology, Volume 331, Issue 2, Page G155-G164, August 2026.

American Journal of Physiology-Renal Physiology, Volume 331, Issue 2, Page F152-F163, August 2026.

American Journal of Physiology-Endocrinology and Metabolism, Volume 331, Issue 2, Page E154-E164, August 2026.

American Journal of Physiology-Renal Physiology, Volume 331, Issue 2, Page F164-F174, August 2026.

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Volume 331, Issue 2, Page R113-R126, August 2026.

American Journal of Physiology-Gastrointestinal and Liver Physiology, Volume 331, Issue 2, Page G140-G154, August 2026.

{"p"=>"The physiology of neurons and synapses determines how networks in the brain process information. While these properties are well described in rodents, they are less well established for the human brain. Increasing availability of surgically resected human brain tissue, together with advances in electrophysiology, has enabled new insights into species-specific differences of the human cortical microcircuit. This review highlights recent progress in the physiology of layer 2 and 3 pyramidal neurons of the human temporal cortex, focusing on the multi-neuron patch-clamp approach. Methodological developments such as automated pipette cleaning now allow large-scale mapping of cellular electrophysiology and synaptic connectivity in human cortex. This approach reveals substantial functional heterogeneity among layer 2 and 3 pyramidal neurons with distinct intrinsic properties, morphology, and connectivity patterns. Complex network analyses further uncover human-specific properties, such as a directed network topology with random reciprocity and a decoupling of synaptic strength from connectivity. Network simulations suggest that these wiring patterns expand the computational capacity of cortical microcircuits. Together, these studies showcase the potential of multipatch recordings to bridge rodent and human neurophysiology and to establish an empirical basis for how cellular and synaptic diversity shapes human cortical microcircuits. "}

American Journal of Physiology-Renal Physiology, Ahead of Print.

American Journal of Physiology-Lung Cellular and Molecular Physiology, Ahead of Print.

{"__content__"=>"\n Objective\n \n \n Methods\n \n \n Results\n \n \n Conclusions\n \n ", "p"=>[{"__content__"=>"To evaluate whether focused foot patrols in harm-weighted micro-places reduce crime frequency and crime harm in Santiago, Chile, relative to business-as-usual patrol allocation."}, {"__content__"=>"Priority Areas were identified by combining hotspot and harmspot criteria using the Chilean Crime Harm Index. Forty-nine street segments were assigned to receive three daily foot patrol visits and 110 served as controls. Effects were estimated using covariate-adjusted intention-to-treat (ITT) Difference-in-Differences models that retained all randomized Priority Areas while adjusting for baseline imbalance, stratification cluster, proximity to Metro stations, and implementation violations where relevant."}, {"__content__"=>"The primary ITT analysis did not identify statistically significant reductions in overall crime frequency or overall crime harm. Secondary implementation-sensitive analyses showed larger, though still non-significant, aggregate reductions in treated areas. Theoretically informed offence-category analyses, however, identified significant reductions in the combined category of Assaults, Public Consumption of Alcohol or Drugs, and Street Vending without Licence. Cost-effectiveness analyses indicated that the intervention performed more efficiently than the standard quadrant-based patrol model under the restricted implementation-sensitive specification."}, {"__content__"=>"The findings suggest that focused foot patrols in harm-weighted micro-places can reduce visible and guardianship-sensitive offences, even under conditions of low dosage and implementation constraints. More broadly, the study shows that randomized policing trials may generate different conclusions depending on whether analyses estimate assignment effects, implementation-sensitive contrasts, or theoretically targeted offence outcomes."}]}

There is no abstract available for this paper.

American Journal of Physiology-Lung Cellular and Molecular Physiology, Ahead of Print.

{"p"=>"This conceptual review provides a synthesising narrative of the interdependent regulation of intracellular pH (pHi), nitric oxide (NO), and adenosine—the pHi–NO–adenosine triad—in fetoplacental endothelial dysfunction associated with gestational diabetes mellitus (GDM). GDM is associated with fetoplacental endothelial dysfunction, involving altered nitric oxide (NO) synthesis, reduced adenosine uptake, and dysregulated intracellular pH (pHi). Human umbilical vein endothelial cells (HUVECs) from GDM pregnancies exhibit increased endothelial NO synthase activity and decreased adenosine transport via human equilibrative nucleoside transporters, processes modulated by NO and pHi. These changes converge in the ALANO (Adenosine/L-Arginine/Nitric Oxide) signalling pathway, which enhances NO synthesis through increased L-arginine uptake. Importantly, similar mechanisms are observed in both macrovascular and microvascular endothelial cells, suggesting widespread placental vascular involvement. Maternal pre-pregnancy body mass index stratification reveals further heterogeneity in these responses. Disruptions in this signalling triad, i.e. NO, adenosine, and pHi, may impair placental perfusion, nutrient delivery, and fetal development, with potential long-term cardiometabolic consequences. Understanding these interrelated mechanisms provides a framework for targeted interventions in GDM, emphasizing the need for personalized approaches in maternal-foetal medicine."}

There is no abstract available for this paper.

{"p"=>{"__content__"=>"This article situates beggary legislation in India within a long penal trajectory that runs from colonial vagrancy codes to the Bombay Prevention of Begging Act, 1959, and its various clones enacted in different states of India. It shows how the destitute are governed through categories of public order, nuisance, and threat to public hygiene, turning a condition of deprivation into an offence. Drawing on statutes, court judgements, secondary scholarship, and field experience, it maps the continuities in law and institution, and the ethical incoherence of a welfare state that deals with destitution through detention. Recent judgements, Ram Lakhan (), Harsh Mander (), and Suhail Rashid Bhat (), signal a turn towards dignity and care, yet the road ahead still seems long as beggary laws continue to operate in more than twenty states and union territories of India. Anchored alongside the 2016 Model Bill on destitution, the SMILE Scheme and related policy schemes, the paper argues for replacing punitive measures with protection, care, and rehabilitation rooted in constitutional morality, social justice, rights, and inclusion.", "CitationRef"=>[{"__content__"=>"2006", "CitationID"=>"CR47"}, {"__content__"=>"2018", "CitationID"=>"CR29"}, {"__content__"=>"2019", "CitationID"=>"CR52"}]}}

{"p"=>"The article examines changes in ordinary criminal law in postcolonial India, focusing on three forms of punishment—life imprisonment, death penalty and minimum mandatory sentencing. The methodology includes a survey of changes in the legislative text, Constitutional provisions of due process, judgments of the Supreme Court of India and the reports and recommendations of the Law Commission of India. The analysis reveals that despite due process rights and amendments to the criminal regime claiming decolonization, punishment in postcolonial India has increasingly become hyper-punitive, revealing residues of colonialism as well as its nexus with the global rise of new technologies of crime and social control."}

{"p"=>"In this article, we propose a critical criminology of war that is informed by Stanley Cohen’s notion of states of denial and his portrayal of Israel as a “special case” in this respect. After a general introduction into the development of the criminology of war, we focus on two analytical lines, namely (1) the notion that a culture of denial is indispensable in the legitimation of war and war crimes and (2) that postcolonial thinking can explain why different conflicts are framed differently in different countries, and that the differences between the global North and the global South are the most fundamental in this respect. We argue how the Israeli-Palestinian conflict is probably the most illustrative in this respect and single out that particular conflict in the remainder of our analysis. We analyse the narratives that are used to deny the atrocities Israel is accused of and how other events are reframed in a way that best suits Israel’s political interests."}

{"p"=>"The death penalty in sub-Saharan Africa remains a contentious issue: twenty-eight states have abolished the penalty, and twenty-one retain it. This paper situates the use or disuse of capital punishment as a legacy of colonialism. Colonialism created conditions of ethnic fragmentation and economic vulnerability that prevented a meaningful transition to democracy at independence, resulting in weak states that relied on state violence to maintain power. Differing forms of colonial governance impacted the centrality of the death penalty to state power, and this paper addresses the distinction between direct rule and indirect rule in explaining why British Africa tends to retain the death penalty and the rest of Africa has tended to abolish."}

{"__content__"=>"\n Purpose\n \n \n Methods\n \n \n Results\n \n \n Conclusion\n \n ", "p"=>[{"__content__"=>"This study evaluated videos designed to promote cyber hygiene intentions, informed by Protection Motivation Theory (PMT)."}, {"__content__"=>"We recruited 437 U.S. adults through an online platform and randomly assigned them to one of three conditions: a narrative video, a didactic video, or a text-based control message describing the phishing threat. Participants completed pre- and post-surveys measuring cyber hygiene, PMT constructs, and individual traits."}, {"__content__"=>"Results indicated that both video formats increased cyber hygiene intentions compared to the text-based control. There was no statistically meaningful difference between the narrative and didactic formats, suggesting that delivery style alone does not materially alter cybersecurity intentions when content is held constant, although the narrative showed numerically larger effects. The main predictors of protection motivation included response efficacy, vulnerability, severity, and response costs; fear and self-efficacy were not significant. Technical skill and reflective decision-making positively influenced protective intentions, whereas self-control did not. Mediation analyses suggested that PMT constructs are associated with pathways linking the videos to cyber hygiene, although the cross-sectional measurement of mediators limits strong causal inference."}, {"__content__"=>"Overall, the findings support the use of video-based cybersecurity training that emphasizes actionable guidance rather than emotional arousal."}]}

American Journal of Physiology-Lung Cellular and Molecular Physiology, Volume 331, Issue 2, Page L155-L164, August 2026.

American Journal of Physiology-Endocrinology and Metabolism, Volume 331, Issue 2, Page E148-E153, August 2026.

American Journal of Physiology-Cell Physiology, Volume 331, Issue 2, Page C316-C327, August 2026.

American Journal of Physiology-Endocrinology and Metabolism, Volume 331, Issue 2, Page E131-E147, August 2026.

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Ahead of Print.

American Journal of Physiology-Endocrinology and Metabolism, Ahead of Print.

{"__content__"=>"\n Abstract\n \n \n Registration\n \n ", "p"=>[{"__content__"=>"Adverse childhood experiences (ACEs) significantly influence the development of suicidal ideation (SI) in young people. Psychological factors are critical mediators in this relationship, yet the underlying psychological mechanisms remain unclear. This study aims to identify the psychological mediating/moderating factors between ACEs and SI among young people, thereby providing scientific evidence and theoretical support for formulating targeted psychological intervention strategies and reducing the risk of suicide. We searched six databases (PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wan Fang) from their inception to June 23rd, 2025. Eligible studies were cross-sectional or cohort designs investigating psychological mediators/moderators between ACEs and SI in young people. The methodological quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal checklists for cross-sectional studies and the Newcastle-Ottawa Scale for longitudinal studies. The results were synthesized using a narrative synthesis. This systematic review was reported in accordance with the PRISMA 2020 guideline. Among the 54 included studies, we identified 45 psychological mediating/moderating factors. These factors are classified as protecting and deteriorating factors. Among them, we found that negative emotions, negative thought patterns, and positive psychological traits were the mostfrequently examined factors. This study further summarizes the potential psychological pathways linking ACEs and SI in young people, thereby clarifying future intervention directions. It also suggests that future intervention programs should be diversified and targeted, so as to intervene early in young people’s SI and reduce their suicide risk. Future longitudinal cohort studies should verify the temporal and causal relationships suggested by this review."}, {"__content__"=>"The protocol has been registered in PROSPERO (ID CRD420251054107)."}]}

{"__content__"=>"\n Graphical abstract\n \n ", "p"=>[{"__content__"=>"Aluminum (Al³⁺) is a widespread environmental metal with potential effects on the intestinal epithelium. In this study, we evaluated the impact of dietary concentrations of aluminum on barrier integrity, histological organization, and gene expression in a 3D human intestinal tissue model. Tissues were exposed to increasing concentrations of aluminum (0, 5, 20, and 50 ppm) for 12 days to mimic environmental chronic exposure through ingestion. Transepithelial electrical resistance (TEER) measurements revealed a significant decrease only at the highest dose (50 ppm) on day 12, indicating a damage to the epithelial permeability. This was supported by a marked downregulation of OCLN and CLDN-5 expression, key genes involved in tight junction integrity. Aluminum permeation across the tissue was confirmed via Inductively Coupled Plasma—Atomic Emission Spectroscopy (ICP-AES), indicating dose-dependent penetration. Furthermore, gene expression analysis showed significant upregulation of MT-1E and MT-2 A (markers of cellular response to metal exposure) while MT-1 A remained unchanged. The present data demonstrate that repeated exposure to 50 ppm of Al3+ impacts intestinal barrier function and alters the tissue organization in the human intestinal epithelium."}, {}]}

American Journal of Physiology-Renal Physiology, Ahead of Print.

American Journal of Physiology-Renal Physiology, Ahead of Print.

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Ahead of Print.