Synergistic enhancement of skull bone regeneration in rats using demineralized dentin matrix dual-loaded with BMP-2 and NELL-1 growth factors

Ruwei Wang, Linlin Xu, Qiang Wang, Department of Central Laboratory, Jinan Stomatological Hospital , Jinan Key Laboratory of Oral Diseases and Tissue Regeneration , Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration , Shandong Province

Journal of Biomaterials Applications

Published online on May 05, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
To address the limitations associated with current bone graft materials, particularly the slow resorption of deproteinized bovine bone minerals and the adverse effects of high-dose BMP-2, we developed an innovative tripartite regeneration platform. This ...