Development and in vivo evaluation of a self-polymerizable tranilast-loaded silicone gel for scar modulation

Farjam Goudarzi, Daniel Elieh-Ali-Komi, Sara Derakhshan, Khodabakhsh Rashidi, Amir Kiani, Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Institute of Allergology, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology

Journal of Biomaterials Applications

Published online on March 13, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
Hypertrophic scars and keloids represent pathological outcomes of wound healing characterized by excessive collagen deposition and persistent myofibroblast activity, necessitating effective therapeutic intervention. In this study, a self-polymerizable one-...