Non-clinical safety of novel cross-linked chondroitin sulfate (SI-449) as an anti-adhesion barrier for abdominal and pelvic surgeries

Ayako Shiraki, Shino Ito, Dai Muramatsu, Tomoki Sasaki, Akira Otsuka, Tomomi Miyahara, Katsuya Takahashi, Keiji Yoshioka, Miki Suehiro, Central Research Laboratory, Development Division, Seikagaku Corporation, D Strategy, Development Division, Seikagaku Corporation

Journal of Biomaterials Applications

Published online on March 27, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
Postoperative adhesions result from abnormal tissue repair and most frequently occur in patients following abdominal and pelvic surgeries. Prevention of adhesion formation, including the use of anti-adhesion barriers during surgery, is considered the most ...