This manuscript presents the blind prediction of fatigue life performance in three laminated carbon fiber reinforced polymer composite layups using a reduced-order space-time homogenization model. To bridge the spatial scales, the modeling approach relies on the Eigendeformation-based reduced order homogenization method. To bridge the time scales associated with a single load cycle and the overall life of the composite, a homogenization-based accelerated multiple-time-scale integrator with adaptive time stepping capability is employed. The proposed multiscale modeling approach was used to predict the evolution of composite stiffness and progressive damage accumulation as a function of loading cycles, as well as residual strength after fatigue in tension and compression, for three layups ([0,45,90,–45]_2s, [30,60,90,–60,–30]_2s, and [60,0,–60]_3s). Following blind prediction, the experimental data from the blind prediction specimens were employed to better understand the failure mechanisms and recalibrate the model. This study was performed as a part of the Air Force Research Laboratory's "Damage Tolerant Design Principles" Program.