This study considers how employees’ tenacity might enhance their propensity to engage in knowledge exchange with organizational peers, as well as how the positive tenacity–knowledge exchange relationship is invigorated by two types of role conflict: within-work and between work and family. Using data from a large Mexican organization in the logistics sector, this study shows that tenacity increases knowledge exchange, and this effect is stronger at higher levels of within-work and work–family role conflict. The invigorating role of within-work role conflict is particularly salient when work–family role conflict is high. These findings inform organizations that the application of personal energy to knowledge-enhancing activities is particularly useful when employees encounter severe workplace adversity because of conflicting role demands.