This investigation assessed whether alcohol consumption was negatively related to grade point average (GPA) among a nationally representative sample of college students. Items from the American College Health Association’s National College Health Assessment (N = 22,424) were investigated. One-way ANOVAs and logistic regression analyses were conducted. Results revealed that respondents with lower GPAs consumed a greater number of drinks compared with those with higher GPAs. Students with higher GPAs engaged in heavy episodic drinking less than students with lower GPAs. Number of drinks consumed was the strongest predictor of academic performance; the likelihood of being an A student decreased with each drink consumed. Similarly, binge drinking was the strongest predictor; the likelihood of being an A student decreased as binge drinking increased. The dynamic, interdependent relationship between alcohol and GPA documented herein confirms previous research, which delineates reduced academic performance as a function of alcohol consumption.