The connection between oral and systemic health is becoming more obvious. Oral infections, specifically periodontitis, have been associated with diseases such as diabetes, cardiovascular disease, respiratory infection, erectile dysfunction, metabolic syndrome, and rheumatoid arthritis, to name a few. As people age, they become more susceptible for developing both oral and systemic diseases. This article discusses the oral-systemic relationship as well as sheds light on preventive measures that can be taken.