The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention

Ke-Wu, D., Xu-Bo, S., Ying-Xin, Z., Shi-Wei, Y., Yu-Jie, Z., Dong-Mei, S., Yu-Yang, L., De-An, J., Zhe, F., Zhi-Ming, Z., Hai-Long, G., Zhen-Xian, Y., Chang-Sheng, M.

Angiology: The Journal of Vascular Diseases

Published online on December 23, 2013

Abstract

Objective:

To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).

Method:

Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3.

Results:

Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively).

Conclusion:

Exogenous CP was helpful to reduce myocardial injury after PCI.