Plasma Biomarkers and Clinical Indicators for Identifying Mild Cognitive Impairment in Older Adults With Psychiatric Disorders

Camilla Elefante, Maria Francesca Beatino, Daniela Marro, Andrea Coccoglioniti, Cosimo Lazzerini, Andrea Pacini, Ani Gasparyan, Esther Caparrós, Lucia Petrozzi, Gabriele Siciliano, Zahinoor Ismail, Lorenzo Lattanzi, Filippo Baldacci, Roberto Ceravolo, Giulio Perugi, Independent Researcher, Department of Mental Health, Azienda USL Toscana Nord Ovest, Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, Hepatic and Intestinal Immunobiology Group, Departamento Medicina Clínica e Instituto IDIBE, Universidad Miguel Hernández, Instituto de Investigación Sanitaria y Biomédica de Alicante, Instituto de Salud Carlos III, Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Departments of Psychiatry, Clinical Neurosciences, Community Health Sciences, and Pathology and Laboratory Medicine, Hotchkiss Brain Institute , Brien Institute for Public Health, University of Calgary, College of Health and Medicine, University of Exeter

Journal of Geriatric Psychiatry and Neurology

Published online on August 13, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
BackgroundMild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) can be prodromal stages of neurodegenerative disease associated with plasma biomarkers of tau pathology and neuroaxonal damage. However, in psychiatric populations, the ...