A Systematic Review of Effects of Cholinesterase Inhibitors and Memantine on Cognitive Domains in Alzheimer’s Disease

Anna Williams, Anish Bandalore Satheesha Reddy, Latha Velayudhan, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, s College London, Department of Psychosis Studies, Institute of Psychiatry, s College London, Centre for Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, s College London, Lewisham Memory Service, Mental Health for Older Adults, South London , Maudsley NHS Foundation Trust, Department of Population Health Sciences, University of Leicester

Journal of Geriatric Psychiatry and Neurology

Published online on August 12, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
BackgroundAlzheimer’s Disease (AD) is characterised by progressive cognitive decline. Cholinesterase inhibitors (ChEI) (donepezil, rivastigmine and galantamine) and memantine have been the mainstay treatment and have showed their effectiveness on total ...