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Stratification in small randomised clinical trials and analysis of covariance: Some simple theory and recommendations

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Statistical Methods in Medical Research: An International Review Journal

Published online on

Abstract

Statistical Methods in Medical Research, Ahead of Print.
A simple device for balancing for a continuous covariate in clinical trials is to stratify by whether the covariate is above or below some target value, typically the predicted median. The object is to improve balance of the covariate and hence efficiency ...