Exchange transfusion through the heart-lung machine in a sickle cell disease patient undergoing aortic valve replacement: proposition for a pragmatic protocol

Nicolas Mavambu, Baptiste Monnier, Virginie Louvain Quintard, Charbel Zaccour, Jacques Thès, Sylvain Diop, Department of Anesthesiology, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson, Cardiothoracic Intensive Care Unit, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson, Cardiothoracic Perfusion Team, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson, Department of Biology and Hemostasis, Marie Lannelongue Hospital, Paris Saint Joseph Hospital, Le Plessis Robinson

Perfusion

Published online on July 31, 2026

Abstract

Perfusion, Ahead of Print.
BackgroundIn sickle cell patients scheduled for cardiac surgery, preoperative decrease in hemoglobin S (HbS) by exchange transfusion is advocated; however, protocol may vary according to institution. In this report, we provide a standardized framework ...