Beyond glycemic control: clinical cardiovascular effects of tirzepatide—a narrative review

Azza O. Alawad, Tarig H. Merghani, Tarig E. Fadelelmoula, Nasir Abdelrafie Elamin, Shahenaz Satti, Alhiedi Ali Edris, Alwaleed Hakim, Rima Fathi El-Hindi, Ahmed Abdalla Alhaj-Ali, Wasil Elnour Ibrahim, Muhanad Ahmed Mustafa, Maymouna Mohieldin Sirelkhatim, Hany Hatim Ahmed, Nadia Osman Yousif

Therapeutic Advances in Endocrinology and Metabolism

Published online on July 28, 2026

Abstract

Therapeutic Advances in Endocrinology and Metabolism, Volume 17, January-December 2026.
The risk of cardiovascular disease is significantly increased by both type 2 diabetes mellitus (T2DM) and obesity through overlapping pathways involving insulin resistance, dyslipidemia, systemic inflammation, and endothelial dysfunction. Tirzepatide, the ...