Inaugural complete heart block in anti-SSA negative systemic lupus erythematosus: the diagnostic role of anti-PM-Scl 100 antibodies

Nadia Dammene Debbih, Leila Laouar, Nassima Dekdouk, Houda Belguendouz, Riad Benkouar, Mohamed Seddik Aït Messaoudène, Department of Cardiology, Mustapha University Hospital, University of Algiers , Faculty of Medicine, Department of Pneumology, Mustapha University Hospital, University of Algiers , Faculty of Medicine, Forensic Service , Penitentiary Unit, Mustapha University Hospital, Department of Cellular and Molecular Biology, University of Science and Technology Houari Boumediene Faculty of Biological Sciences

Lupus: An International Journal

Published online on July 29, 2026

Abstract

Lupus, Ahead of Print.
IntroductionComplete heart block (CHB) is an exceptionally rare manifestation of adult systemic lupus erythematosus (SLE), typically occurring in less than 1% of patients. While classically associated with anti-SSA/Ro antibodies, we report a rare case of ...