The Use of a Handheld Non-Invasive Vagal Nerve Stimulation (nVNS) Device for the Treatment of Long COVID: A Pilot Randomized Controlled Trial

Ravindra Ganesh, Siddhant Yadav, Darrell R. Schroeder, Ivana T. Croghan, Jennifer Hanson, Megan Erickson, Shawn Fokken, Sara Seegmiller, Stephanie L. Grach, Elizabeth A. Gilman, Ryan T. Hurt, Michael R. Mueller, Department of Internal Medicine, Division of General Internal Medicine, Mayo Clinic, Department of Quantitative Health Sciences, Mayo Clinic, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Department of Internal Medicine, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic

Journal of Primary Care & Community Health

Published online on July 25, 2026

Abstract

Journal of Primary Care & Community Health, Volume 17, January-December 2026.
ObjectivesLong-term symptoms following infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2), termed post-acute sequelae of SARS-CoV-2 infection (PASC) or Long COVID (LC), persist beyond 90 days and may impact at least 10% of patients with ...