Brain age gap in multiple sclerosis: associated with disability but independent of serum biomarkers

Marc Pawlitzki, Patricia Kirschner, Lars Masanneck, Ramona Hagler, Elias Meier, Marius Vach, Hernan Inojosa, Tjalf Ziemssen, Vivien Lorena Ivan, Shammi More, Kaustubh Patil, Parnian Firouzi-Memarpuri, Julian Caspers, Jonathan Repple, Udo Dannlowski, Michael Khalil, Sven G. Meuth, Christian Rubbert

Therapeutic Advances in Neurological Disorders

Published online on June 23, 2026

Abstract

Therapeutic Advances in Neurological Disorders, Volume 19, January-December 2026.
Background:Multiple sclerosis (MS) is influenced by age-related brain alterations and affects cellular aging mechanisms. Machine-learning models can estimate brain-predicted age from magnetic resonance imaging (MRI) to quantify these aging-related ...