Alpha-Gal Syndrome—A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements

Kian Lari, Shahzeb Leghari, Alan M Smeltz, Dillon Patel, Emily G Teeter, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill

Seminars in Cardiothoracic and Vascular Anesthesia

Published online on June 30, 2026

Abstract

Seminars in Cardiothoracic and Vascular Anesthesia, Ahead of Print.
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity to galactose-α-1,3-galactose, an oligosaccharide found in mammalian tissues, including bovine or porcine-derived bioprosthetic valves and heparin. Concerns exist regarding perioperative ...