Brain-on-a-Chip and Blood-Brain Barrier–on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress

Duraisamy Kempuraj, Huachen Shi, Travis D. Truong, Daniel Kong, Arjun Sharma, Prathiv Raj Ramesh Babu, Mohit G. Belur, Sai Puneeth Kothuru, Baskaran Chinnappan, Claudia Pena, Prarthana Patel, Avi Shah, Divya Komandooru, Daniel Seth Valladares, Thomas Freeman, Theoharis C. Theoharides

The Neuroscientist: Reviews at the Interface of Basic and Clinical Neurosciences

Published online on June 23, 2026

Abstract

The Neuroscientist, Volume 32, Issue 4, Page 253-269, August 2026.
Brain-on-a-chip is a microphysiologic platform that comprises cultured brain cells to understand brain disease pathogenesis and treatment. The blood-brain barrier (BBB) of the neurovascular unit serves as a highly selective molecular transport interface ...