Aldose Reductase Inhibitor, Epalrestat, Suppresses Colorectal Cancer Cell Proliferation Through Complement-Dependent Cytotoxicity

Dongxu Peng, Zhengsheng Yi, Yidan Chen, Yanxia Xu, Nan Zhang, Liping Zheng, Zhuocheng He, Department of Radiation Oncology, Zhuhai People, s Hospital, Zhuhai Clinical Medical College of Jinan University, Department of Oncology, Zhuhai People, s Hospital, Zhuhai Clinical Medical College of Jinan University

International Journal of Toxicology

Published online on June 29, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
Complement-dependent cytotoxicity (CDC) is critical for tumor cell proliferation. Previous work has revealed that epalrestat (EPA), an inhibitor of aldose reductase, plays a crucial role in tumor cell proliferation. However, whether CDC is involved in EPA-...