Assay-dependent Artifactual Prolongation of Activated Partial Thromboplastin Time (aPTT) in Cynomolgus Monkeys: Potential Role of POEGMA
International Journal of Toxicology
Published online on July 23, 2026
Abstract
International Journal of Toxicology, Ahead of Print.
We identified an assay-dependent, artifactual prolongation of activated partial thromboplastin time (aPTT) during nonclinical safety studies of an enzyme biologic conjugated with a next-generation polyethylene glycol (PEG)-like stealth polymer, poly(...
We identified an assay-dependent, artifactual prolongation of activated partial thromboplastin time (aPTT) during nonclinical safety studies of an enzyme biologic conjugated with a next-generation polyethylene glycol (PEG)-like stealth polymer, poly(...