MDM4 Amplification in Liposarcoma: A Rare Finding or an Underrecognized Pathway?
International Journal of Surgical Pathology
Published online on July 21, 2026
Abstract
International Journal of Surgical Pathology, Ahead of Print.
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is typically characterized byMDM2and/orCDK4amplification. However, a subset lacks these alterations, suggesting alternative oncogenic drivers. We report a patient with recurrent ...
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is typically characterized byMDM2and/orCDK4amplification. However, a subset lacks these alterations, suggesting alternative oncogenic drivers. We report a patient with recurrent ...