Citrullinated Histone 3 as a Marker of NETosis at Opposite Ends of Hemostasis: Evidence From Thrombosis-Prone MPN and Bleeding-Prone Hemophilia

Sercan Olcar, Tuğrul Elverdi, İbrahim Murat Bolayırlı, Ahmet Emre Eşkazan, Deniz Özmen, Melis Dila Özer Çerme, Ayşe Salihoğlu, Zafer Başlar, Muhlis Cem Ar, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Division of Hematology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Department of Biochemistry, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa

Clinical and Applied Thrombosis/Hemostasis

Published online on June 22, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundNeutrophil extracellular trap (NET) formation has emerged as a key driver of thrombosis in myeloproliferative neoplasms (MPNs). Its role in congenital bleeding disorders, however, remains unexplored.ObjectivesTo investigate circulating ...