Flexible Survival Extrapolation with Blended Hazards: Accounting for Treatment Effect Waning in Health Technology Assessment
Published online on June 19, 2026
Abstract
Medical Decision Making, Ahead of Print.
BackgroundSurvival extrapolation is crucial in estimating the lifetime survival benefit of a treatment for health technology assessment (HTA). Conventional extrapolation methods, which assume that the long-term treatment effect (hazard ratio between ...
BackgroundSurvival extrapolation is crucial in estimating the lifetime survival benefit of a treatment for health technology assessment (HTA). Conventional extrapolation methods, which assume that the long-term treatment effect (hazard ratio between ...