From clinical to immunologic remission in lupus nephritis: Toward MRD-grade B-cell depletion

Lucas Maciel de Almeida Corrêa, Luiggi Kevin Virgino Brandão, Clara Belo Gamon Santiago, Alexandre de Assis Barbosa, Gabriel Rian Mazur, Gabriel Costa de Santana, Yan Roberth Delmiro Silva, Letícia Esteves Dante, Ivan Felipe Dutra Júnior, Department of Nephrology, Faculdade de Medicina de São José do Rio Preto , São José do Rio Preto, São Paulo, School of Medicine, Centro Universitário Uninorte , Rio Branco, School of Medicine, Universidade Estadual de Mato Grosso do Sul , Campo Grande, Mato Grosso do Sul, School of Medicine, Pontifícia Universidade Católica do Paraná , School of Medicine, Universidade Salvador , School of Medicine, Universidade Federal de Alagoas

Lupus: An International Journal

Published online on June 03, 2026

Abstract

Lupus, Ahead of Print.
Current B-cell depletion strategies in lupus nephritis (LN) may encounter a mechanistic “glass ceiling.” While rituximab remains an important therapeutic option, its activity can be constrained by CD20 internalization, antigenic modulation, and greater ...