Mild Behavioural Impairment and Everyday Functioning in Cognitively Unimpaired Older Adults: Evidence From the CAN-PROTECT Study

Maryam Ghahremani, Dylan X. Guan, Clive Ballard, Byron Creese, Anne Corbett, Ellie Pickering, Eric E. Smith, Zahinoor Ismail, Department of Psychiatry, Cumming School of Medicine, University of Calgary, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Department of Psychology, College of Health Medicine and Life Sciences, Brunel University of London, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Community Health Sciences, Cumming School of Medicine, University of Calgary, Department of Pathology and Laboratory Medicine, University of Calgary, Brien Institute for Public Health, Cumming School of Medicine, University of Calgary

Journal of Geriatric Psychiatry and Neurology

Published online on June 14, 2026

Abstract

Journal of Geriatric Psychiatry and Neurology, Ahead of Print.
BackgroundRecognizing early clinical signs of dementia is key to optimizing emerging therapies, including monoclonal antibodies. Mild behavioural impairment (MBI) characterizes later-life emergent and persistent nropsychiatric symptoms linked to greater ...