Safety Assessment of Glycolactones as Used in Cosmetics

Priya Ferguson, Wilma F. Bergfeld, Donald V. Belsito, David E. Cohen, Curtis D. Klaassen, Daniel C. Liebler, Lisa A. Peterson, Allan E. Rettie, David Ross, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Susan C. Tilton, Monice M. Fiume, Bart Heldreth, Cosmetic Ingredient Review Associate Toxicologist, Senior Scientific Analyst, Expert Panel for Cosmetic Ingredient Safety Member, Expert Panel for Cosmetic Ingredient Safety Former Member, Cosmetic Ingredient Review Senior Director, Cosmetic Ingredient Review Executive Director

International Journal of Toxicology

Published online on June 06, 2026

Abstract

International Journal of Toxicology, Volume 45, Issue 2_suppl, Page 124S-134S, July-August 2026.
The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 glycolactone ingredients. Glucoheptonolactone and Gluconolactone are reported to function in cosmetics as skin-conditioning agents—miscellaneous, and Gluconolactone is also ...