Evaluation of the in vitro Toxicity of Novel Oxime Acetylcholinesterase Reactivators

Janice E. Chambers, Center for Environmental Health Sciences, Department of Comparative Biomedical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State

International Journal of Toxicology

Published online on June 14, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
War and terrorism demonstrate the need for an improved antidote against nerve agents that cause brain damage following inhibition of acetylcholinesterase (AChE). Our laboratories invented substituted phenoxyalkyl pyridinium oxime AChE reactivators (US ...