Hitching a Ride to Overcome Barriers: Nonclinical Safety Considerations for Bioconjugated Oligonucleotides

Sheroy Minocherhomji, Katie Sokolowski, Kelle Franklin, Laura Leung, Eileen Blasi, Tae-Won Kim, Eli Lilly and Company, Denali Therapeutics, South San Francisco, Avidity Biosciences, A Novartis Company, La Jolla, Ca Usa, Ionis Pharmaceuticals, Ca Usa

International Journal of Toxicology

Published online on June 04, 2026

Abstract

International Journal of Toxicology, Ahead of Print.
Advances in the delivery and safety of nucleic acid-based therapeutics are enabling tissue-selective targeting and broadening the reach of genetic medicines. In addition to GalNAc-conjugated oligonucleotides, newer modalities—predominantly antibody- and ...