Left Atrial Appendage Closure versus Oral Anticoagulants in Patients with Atrial Fibrillation: Systematic Review

Heng Liu, Zhangbin Li, Xiaoqing Chen, Junjie Zhou, Department of Cardiology, Heyuan People, s Hospital, Department of Cardiology, Heyuan People, s Hospital, The First Clinical College of Guangdong Medical University, Department of Critical Care Medicine, Heyuan People, s Hospital

Clinical and Applied Thrombosis/Hemostasis

Published online on June 09, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundOral anticoagulants (OACs) remain the standard strategy for stroke prevention in atrial fibrillation (AF) but are limited by bleeding risk, intolerance, and long-term adherence challenges. Left atrial appendage closure (LAAC) has emerged as a ...