Immune Cell Composition and Protein Biomarkers Correlate With PRP Treatment Outcomes in Knee Osteoarthritis

Lea Zila, Juliane D. Glaeser, Julia Sheyn, Giselle Kaneda, Jacob T. Wechsler, Parnika Karthik, Victoria Yu, Jasmine Galloway, Begonya Comin-Anduix, Sarah Parker, Aleksander Stotland, Catherine Bresee, Khosrowdad Salehi, Pablo Avalos, Clive N. Svendsen, Wafa Tawackoli, Bert Mandelbaum, Dmitriy Sheyn

Orthopaedic Journal of Sports Medicine

Published online on May 19, 2026

Abstract

Orthopaedic Journal of Sports Medicine, Volume 14, Issue 5, May 2026.
Background:Current treatments for osteoarthritis (OA) include physical therapy, nonsteroidal anti-inflammatory drugs, and joint arthroplasty, which aim to address symptoms rather than modify disease progression. Autologous platelet-rich plasma (PRP) and ...