Microcirculatory effects of cardiopulmonary bypass primings in coronary artery bypass graft surgery the prime randomised clinical trial for a physiological proof-of-principle

Anne M. Beukers, Jord C. Seegers, Nikki van Haasteren, Meike Brouwers, Ruben J. Bosch, Anita M. Tuip-de Boer, Charissa E. van den Brom, Susanne Eberl, Floor J. Mansvelder, Gudrun Kunst, David M.P. van Meenen, Carolien S.E. Bulte, Stephan A. Loer, Alexander Vonk, Department of Anaesthesiology, Amsterdam University Medical Centre, The Netherlands, Department of Intensive Care Medicine, Amsterdam University Medical Centre, The Netherlands, Department of Cardiothoracic Surgery, Amsterdam University Medical Centre, The Netherlands, Department of Clinical Perfusion, Antonius Hospital, The Netherlands, Laboratory for Experimental Intensive Care and Anaesthesiology , Amsterdam University Medical Centre, The Netherlands, Department of Anaesthesiology, s College Hospital, The United Kingdom

Perfusion

Published online on May 16, 2026

Abstract

Perfusion, Ahead of Print.
ObjectivesCardiopulmonary bypass (CPB) impairs endothelial function, causing oedema and disturbed microcirculatory perfusion, that contribute to organ dysfunction following cardiac surgery. We hypothesised that the composition of CPB prime fluids with ...