Direct Oral Anticoagulants Increase Overall but Not Major Bleeding in Critically Ill Chronic Kidney Disease Patients With Pulmonary Embolism

Zi-Kang Zhou, Qin-Yi Xu, Jia-Lu Ping, Hao-Nan Chen, Song-Tao Shou, Yan-Cun Liu, Department of Emergency Medicine, Tianjin Medical University General Hospital, Graduate School, Tianjin Medical University

Clinical and Applied Thrombosis/Hemostasis

Published online on May 15, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundPatients with pulmonary embolism (PE) and chronic kidney disease (CKD) have a fragile hemostatic balance, yet evidence comparing bleeding risk between direct oral anticoagulants (DOACs) and warfarin in critically ill patients remains limited. We ...