Safety Evaluation of Intranasal Nalmefene in Juvenile Rat Studies in Support of Clinical Trials in Pediatric Patients From Birth to 12 Years of Age
International Journal of Toxicology
Published online on May 15, 2026
Abstract
International Journal of Toxicology, Ahead of Print.
Nalmefene is an opioid antagonist used in OPVEE®nasal spray approved for use in patients 12 years of age and older. To support future clinical studies in younger pediatric populations, 2 GLP juvenile rat studies were conducted to assess the safety of ...
Nalmefene is an opioid antagonist used in OPVEE®nasal spray approved for use in patients 12 years of age and older. To support future clinical studies in younger pediatric populations, 2 GLP juvenile rat studies were conducted to assess the safety of ...