["Psychology in the Schools, EarlyView. ", "\nABSTRACT\nMany Catholic schools face resource challenges that result in limitations surrounding the implementation of multi‐tiered systems and support (MTSS). Artificial intelligence (AI) offers a potential tool for Catholic schools to strengthen systems of support. This article provides a conceptual analysis regarding opportunities for AI to strengthen core components of MTSS, such as identifying evidence‐based interventions, developing progress monitoring tools, analyzing student data, and facilitating personalized instruction. The article also discusses the challenges and limitations of leveraging AI within Catholic schools, specifically when supporting staff and students. Although the article is focused on US contexts, there are conceptual implications that may extend to Catholic schools' systems internationally, specifically related to strengthening the mission of Catholic education. Future researchers should consider evaluating and analyzing the implementation of AI tools within MTSS, specifically how AI tools may support Catholic schools with resource limitations, time constraints, and expertise barriers."]