Is pulse pressure a mediator in the relationship between hyperoxemia and acute brain injury in veno-arterial extracorporeal membrane oxygenation (VA-ECMO) patients? An ELSO registry study

Leon Fan, Winnie L. Liu, Shi Nan Feng, Yaman B. Ahmed, Matteo Di Nardo, Melissa A. Vogelsong, Aniket S. Rali, Akram M. Zaaqoq, Daniel Brodie, Glenn J.R. Whitman, Sung-Min Choon behalf of the HERALD team, Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Pediatric Intensive Care Unit, s Hospital Bambino Gesù, Department of Anesthesiology, and Pain Medicine, Stanford University School of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Department of Anesthesiology and Critical Care, University of Virginia, Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins School of Medicine, Md Usa, Division of Neuroscience Critical Care, Departments of Neurosurgery, Critical Care Medicine, The Johns Hopkins Hospital, Department of Neurology, Johns Hopkins University School of Medicine

Perfusion

Published online on May 06, 2026

Abstract

Perfusion, Volume 41, Issue 1_suppl, Page 126S-136S, May 2026.
IntroductionHyperoxemia is associated with increased mortality and acute brain injury (ABI) in patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO), though the role of native cardiac function in this relationship is unclear. ...