Clostridium cuniculi is associated with chronic high-morbidity low-mortality diarrhea in NSG and NSG-related mouse strains

Kerriann M. Casey, Rina Barouch-Bentov, Wencke Reineking, Flavio H. Alonso, Roberta Moorhead, Minoo Fazel, Anibal G. Armien, Francisco A. Uzal, Rachael B. Chanin, Ami S. Bhatt, Sherril L. Green, Stephen A. Felt, Claude M. Nagamine

Veterinary Pathology

Published online on September 20, 2025

Abstract

Veterinary Pathology, Volume 63, Issue 3, Page 528-541, May 2026.
In October 2020, adult male and female NSG (NOD. Cg-PrkdcscidIl2rgtm1Wjl/Sz) mice were reported for diarrhea within a mouse barrier facility. Other immunodeficient strains harboring the SCID (Prkdcscid) orRag(Ragnull) mutations together with theIL2rg(...