Spontaneous clinical and anatomical pathology findings in SDRG rats

Valeria Bertani, Lucia Minoli, Anna de Battisti, Alice Cantachin, Giuliano Turrini, Giulia Forcellini, Riccardo Bazzoni, Anna Slaviero, Leila Abbas, Silvia Guionaud, Giovanni Pellegrini, Francesco Marchesi

Veterinary Pathology

Published online on March 05, 2026

Abstract

Veterinary Pathology, Volume 63, Issue 3, Page 512-527, May 2026.
The SDRG rat, characterized by a Sprague-Dawley (SD) genetic background with deletion ofRag1andIl2rggenes, has deficiencies in B, T, and natural killer (NK) cells, making it a valuable model for preclinical applications such as tissue transplantation/...