Spontaneous and experimentally induced lesions in NOD-scid gamma and other NOD-derived mouse strains

Pedro Ruivo, Renata Mammone, Ileana C. Miranda, Sebastian E. Carrasco, Sebastien Monette, Laura Janke, Heather Sheppard, Charles-Antoine Assenmacher, Denise M. Imai, Alessandra Piersigilli, Sara F. Santagostino, Enrico Radaelli

Veterinary Pathology

Published online on January 02, 2026

Abstract

Veterinary Pathology, Volume 63, Issue 3, Page 397-422, May 2026.
Immunodeficient mice, particularly the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) strain and other non-obese diabetic (NOD)–derived lines are widely used in biomedical research due to their profound immunosuppression, which enables stable engraftment of human ...