Diagnostic accuracy of gray-scale analysis on B-mode ultrasound for identifying intraplaque hemorrhage and lipid-rich necrotic core in carotid plaques

Benjamin Wagner, Sasha Mukhija, Mohamed Kassem, Andrea Wiencierz, Mandy D Müller, Henrik Gensicke, Daniel Staub, Thomas Wolff, Edin Mujagic, Ioannis Tsogkas, Marios Psychogios, M Eline Kooi, Stefan T Engelter, Philippe Lyrer, Leo Bonati, Leo Bonati, Gian Marco De Marchis, Stefan T Engelter, Joachim Fladt, Henrik Gensicke, Andrea S Jauslin, Josefin E Kaufmann, Philippe Lyrer, Sasha Mukhija, Christopher Traenka, Benjamin Wagner, Annaelle Zietz, Tolga D Dittrich, Andrea Wiencierz, Marios Psychogios, Ioannis Tsogkas, Daniel Staub, Edin Mujagic, Thomas Wolff, Mandy D Müller, Mohamed Kassem, M Eline Kooi, Nils PetersBIOPLAQUE Investigators

Vascular Medicine

Published online on February 25, 2026

Abstract

Vascular Medicine, Volume 31, Issue 2, Page 175-184, April 2026.
Background:Intraplaque hemorrhage (IPH) and lipid-rich necrotic core (LRNC) are key markers of carotid plaque vulnerability and stroke risk. Though magnetic resonance imaging (MRI) can detect both, duplex ultrasound is more accessible and may identify ...