CT perfusion ischemic core predicts PH-2 hemorrhagic transformation following intravenous alteplase bridging treatment prior to endovascular thrombectomy

Asaf Honig, Aviva Alpernas, Yoel Schwartzmann, Hen Hallevi, Issa Metanis, Einor Ben-Assayag, Tali Jonas-Kimchi, Udi Sadeh, Hamza Jubran, Oz Haim, Jose Cohen, Ronen R. Leker, Jeremy Molad

Therapeutic Advances in Neurological Disorders

Published online on March 04, 2026

Abstract

Therapeutic Advances in Neurological Disorders, Volume 19, January-December 2026.
Background:Intravenous thrombolysis (IVT) administered as a bridging therapy prior to endovascular thrombectomy (EVT) for acute ischemic stroke may increase the risk of hemorrhagic-transformation (HT). CT-perfusion (CTP) imaging enables quantitative ...