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Hereditary spastic paraplegia: from decades of therapy to future innovations

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Therapeutic Advances in Neurological Disorders

Published online on

Abstract

Therapeutic Advances in Neurological Disorders, Volume 19, January-December 2026.
Hereditary spastic paraplegia (HSP) groups rare, clinically and genetically heterogeneous neurodegenerative disorders, characterized by progressive lower-limb spasticity and weakness. Over the past decades, diagnostic strategies have evolved from pure ...