Clinical characteristics and outcomes in patients with early-onset locally advanced rectal cancer

Andrea Pretta, Riccardo Giampieri, Pina Ziranu, Andrea Bottelli, Clelia Donisi, Elisa Tiberi, Erika Cimbro, Giovanni Randon, Matteo Fraschini, Dario Spanu, Luca Didaci, Veronica Dell, Gianluca Pretta, Stefano Mariani, Marco Puzzoni, Valeria Pusceddu, Rossana Berardi, Filippo Pietrantonio, Gavino Faa, Mario Scartozzi

Therapeutic Advances in Medical Oncology

Published online on February 23, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:The incidence of early-onset colorectal cancer (EO-CRC), defined as a diagnosis before 50 years of age, is increasing worldwide. However, its clinical characteristics and outcomes compared to average-onset colorectal cancer (AO-CRC) remain ...