Fotemustine-containing chemotherapy suggests lower toxicity with comparable efficacy versus high-dose methotrexate-based regimens: a retrospective cohort analysis

Xudong Zhang, Wanyue Zhao, Wenhua Wang, Jingjing Wu, Mengke Fan, Shanshan Ma, Meng Dong, Linan Zhu, Xiaolong Wu, Xiaoyan Feng, Xin Li, Ling Li, Zhenchang Sun, Xinhua Wang, Xiaorui Fu, Zhaoming Li, Jiaqin Yan, Yu Chang, Hui Yu, Feifei Nan, Zhiyuan Zhou, Mengjie Ding, Jieming Zhang, Lei Zhang, Mingzhi Zhang

Therapeutic Advances in Medical Oncology

Published online on March 04, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:Primary central nervous system lymphoma (PCNSL) is a rare but aggressive non-Hodgkin lymphoma. Currently, high-dose methotrexate (HD-MTX)-based chemotherapy remains the standard first-line treatment. Previous clinical trials have reported that ...