Use of serum MKRN3 and DLK1 levels in precocious puberty: association with an MKRN3 pathogenic variant
Therapeutic Advances in Endocrinology and Metabolism
Published online on February 20, 2026
Abstract
Therapeutic Advances in Endocrinology and Metabolism, Volume 17, January-December 2026.
Background:Loss-of-function alterations inMakorin Ring Finger Protein 3(MKRN3) andDelta-like Non-Canonical Notch Ligand 1(DLK1) genes are associated with familial central precocious puberty (CPP) and can result in reduced serum levels of these ...
Background:Loss-of-function alterations inMakorin Ring Finger Protein 3(MKRN3) andDelta-like Non-Canonical Notch Ligand 1(DLK1) genes are associated with familial central precocious puberty (CPP) and can result in reduced serum levels of these ...