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Contribution of DNA methylation predicted leptin to all-cause, cancer, and cardiovascular mortality among US adults aged 50 years and older: findings from NHANES 1999–2002

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Therapeutic Advances in Endocrinology and Metabolism

Published online on

Abstract

Therapeutic Advances in Endocrinology and Metabolism, Volume 17, January-December 2026.
Background:Epigenetic biomarkers may provide novel insights into long-term health risk. DNA methylation (DNAm) predicted leptin has been proposed as an epigenetic proxy related to metabolic regulation, but its association with mortality remains ...