General practitioner–pharmacist collaboration to enhance deprescribing of psychotropics, sedatives, and anticholinergics among older polypharmacy patients in primary care: study protocol of a cluster-randomized controlled trial (PARTNER)

Annette Haerdtlein, Kerstin Bernartz, Sophie Peter, Laura K. Lepenies, Svetlana Puzhko, Yvonne Eberhardt, Michaela Maas, Stephanie Picker-Huchzermeyer, Vita Brisnik, Diana Falomir, Jochen Gensichen, Tim Steimle, Gunnar Huppertz, Michael Koller, Florian Zeman, Patrizio Vanella, Hanna M. Seidling, Achim Mortsiefer, Christiane Muth, Tobias Dreischulte

Therapeutic Advances in Drug Safety

Published online on January 08, 2026

Abstract

Therapeutic Advances in Drug Safety, Volume 17, January-December 2026.
Background:Appropriate deprescribing of psychotropic, sedative, and anticholinergic potentially inappropriate medication (PSA-PIM) in older adults with polypharmacy can reduce the risk of adverse drug reactions, but is inconsistently implemented in ...