Vaccine efficacy estimands and power considerations
Statistical Methods in Medical Research: An International Review Journal
Published online on April 03, 2026
Abstract
Statistical Methods in Medical Research, Ahead of Print.
The ICH E9(R1) addendum stresses the importance of clearly pre-specifying clinically interpretable treatment effect measures (estimands) and proposes different strategies to deal with intercurrent events. In this paper, we consider different estimands of ...
The ICH E9(R1) addendum stresses the importance of clearly pre-specifying clinically interpretable treatment effect measures (estimands) and proposes different strategies to deal with intercurrent events. In this paper, we consider different estimands of ...