When randomization is not random: Allocation bias in small sample, group sequential randomized clinical trials
Statistical Methods in Medical Research: An International Review Journal
Published online on April 30, 2026
Abstract
Statistical Methods in Medical Research, Ahead of Print.
Even in rare diseases, where the sample size is limited and blinding is less frequently implemented, randomized controlled trials are considered the gold standard to prove efficacy. Randomization is used to mitigate bias and regulatory guidance recommend ...
Even in rare diseases, where the sample size is limited and blinding is less frequently implemented, randomized controlled trials are considered the gold standard to prove efficacy. Randomization is used to mitigate bias and regulatory guidance recommend ...